What question did this study set out to answer?

To review in vivo percutaneous absorption of corticosteroids in humans and evaluate practical strategies to improve therapeutic efficacy in resistant dermatoses.

November 5, 2009Dermatologica

In vivo Percutaneous Penetration of Corticoids in Man and Unresolved Problems in Their Efficacy

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Authors

HMHoward I. MaïbachBeiersdorf (Germany)

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Implication

Review demonstrates minimal percutaneous corticosteroid absorption across glabrous skin in humans, suggesting occlusion and increased concentration improve efficacy in resistant dermatoses.

Key Points

To review in vivo percutaneous absorption of corticosteroids in humans and evaluate practical strategies to improve therapeutic efficacy in resistant dermatoses.
Synthesized findings from human in vivo absorption experiments measuring the urinary excretion of carbon-14-labeled hydrocortisone (14C-hydrocortisone).
Assessed penetration dynamics across different glabrous skin sites under standard application, occlusive dressing conditions, and variable drug concentrations.
Topical corticosteroids undergo minimal baseline penetration across the majority of human glabrous skin areas.
Application of occlusive dressings and increased drug concentrations substantially enhance percutaneous absorption, serving as primary methods to overcome treatment resistance.

Cite This Study

Howard I. Maïbach (2009) studied this question.

synapsesocial.com/papers/6a95b85ae9bbfe047c2bee19 https://doi.org/10.1159/000257863

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Implication

Review demonstrates minimal percutaneous corticosteroid absorption across glabrous skin in humans, suggesting occlusion and increased concentration improve efficacy in resistant dermatoses.

In vivo Percutaneous Penetration of Corticoids in Man and Unresolved Problems in Their Efficacy

Discussion

Member takes

Implication

Key Points

Cite This Study

In vivo Percutaneous Penetration of Corticoids in Man and Unresolved Problems in Their Efficacy

Discussion

Member takes

Implication

Key Points

Cite This Study

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