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May 31, 2022Journal of Feline Medicine and SurgeryOpen Access

Non-injection-site soft tissue sarcoma in cats: outcome following adjuvant radiotherapy

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Authors

AZAlenka Lavra ZajcAHAaron HarperJBJérôme Benoît

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Overview

Retrospective study demonstrates long-term tumor control with adjuvant radiotherapy in cats with non-injection-site soft tissue sarcomas, highlighting viable management for microscopic disease.

Key Points

  • To evaluate clinical outcomes and progression-free survival in cats with non-injection-site soft tissue sarcomas treated with adjuvant radiotherapy following surgery.
  • Retrospective review of medical records for N=18 cats (17 extremity, 1 facial) treated with adjuvant radiotherapy to microscopic disease following either a single surgery (n=9) or multiple surgeries for recurrence (n=9).
  • Cats received either hypofractionated radiotherapy (32–36 Gy delivered in weekly 8–9 Gy fractions; n=8) or conventionally fractionated radiotherapy (48–54 Gy delivered in 16–18 3 Gy fractions; n=10), with a median follow-up of 540 days (range 51–3317 days).
  • Tumor recurrence occurred in 44.4% (8/18) of cats overall, with recurrence rates of 37.5% (3/8) in the hypofractionated protocol and 50% (5/10) in the conventionally fractionated protocol.
  • The overall median progression-free interval was 2748 days for 17 evaluable cats, with protocol-stratified median intervals of 164 days for hypofractionated radiotherapy and 2748 days for conventionally fractionated radiotherapy (P = 0.636).

Cite This Study

Zajc et al. (2022) studied this question.

synapsesocial.com/papers/6a7102c4febe604dd709bf86https://doi.org/10.1177/1098612x221098961
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Also Consider

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  1. 1Update on feline soft tissue sarcomas2025
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  4. 4Preoperative sequential chemotherapy and hypofractionated radiotherapy combined with comprehensive surgical resection for high-risk soft tissue sarcomas: a retrospective study2024 · 4 citations
  5. 5Neo-adjuvant radiation and intratumoral immunotherapy followed by surgery: The NARIS trial for extremity soft tissue sarcoma.2026