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Masked Invader: we constructed a “cloaked” bispecific antibody conjugate in which only one antibody is initially biologically active. The other antibody is rendered inert with a coating of photolabile 2-nitrobenzyl groups until its activity is restored on irradiation with UV-A light. Such activatable conjugates could be used to target enzymes and drugs to tumours whilst minimising side effects in the rest of the body.
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Thompson et al. (2007) studied this question.
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