Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 1966Thrombosis and Haemostasis

The Quantitation of Platelet Aggregation Induced by Four Compounds: A Study in Relation to Myocardial Infarction

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Is platelet aggregation altered in patients with acute or prior myocardial infarction compared to controls?

Population

Patients with acute myocardial infarction, patients 3 months to 5 years after an infarct, and three control…

Comparison

In vitro platelet aggregation testing using ADP… vs Three control groups.

Design

Case-control

Authors

JOJessica O’BrienThe Alfred HospitalFPF. C. PathUniversity of LondonJHJ. B. HeywoodClemson University

Discussion

Loading...

Member takes

Implication

Platelet hyperreactivity in MI patients should not yet alter therapy; leaves open its value as a prognostic marker in prospective studies.

Structured PICO

Is platelet aggregation altered in patients with acute or prior myocardial infarction compared to controls?

P
Population
Patients with acute myocardial infarction, patients 3 months to 5 years after an infarct (some receiving anticoagulants, some not), and three control groups.
I
Intervention
In vitro platelet aggregation testing using ADP, 5-H.T., adrenaline, and collagen.
C
Comparator
Three control groups.
O
Outcome
Platelet aggregation response and mean platelet shape.surrogate

Platelet aggregation in response to ADP, 5-H.T., and adrenaline is significantly increased in patients with recent or past myocardial infarction, though individual variability limits its diagnostic utility.

Limitations

  • Wide variation within individuals
  • Much overlap between groups

Cite This Study

O’Brien et al. (1966) studied this question.

synapsesocial.com/papers/6a71047f53da1ffdb507b2a5https://doi.org/10.1055/s-0038-1655660
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1An Abnormal Pattern of Adenosine Diphosphate-Induced Platelet Aggregation in Acute Myocardial Infarction1969 · 45 citations
  2. 2ADP‐induced Platelet Aggregation in Young Female Survivors of Acute Myocardial Infarction and Their Female Controls1985 · 19 citations
  3. 3Whole blood aggregation, thromboxane release and the lyso derivative of platelet activating factor in myocardial infarction and unstable angina1989 · 27 citations
  4. 4Baseline Platelet Aggregation and Major Receptor Expression Predict Subsequent Activity Following Thrombolysis for Acute Myocardial Infarction2000 · 13 citations
  5. 5Platelet Function in Patients Admitted with a Diagnosis of Myocardial Infarction1987 · 55 citations