Plasminogen activators (PAs) are serine proteases converting the inactive proenzyme, plasminogen, into the active protease, plasmin. Plasmin so formed consitutes an important source of proteolytic activity in cells, tissues and biological fluids. Two distinct types of PAs have been identified: tissue-type PA (t-PA), produced by endothelial cells but also other cell types; and urokinase-type PA (u-PA), initially isolated from
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Birger Åstedt (1989) studied this question.
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