March 11, 2014Acta PhysiologicaOpen Access

High‐fat diet, obesity and sudden cardiac death

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Population

Rabbit model of obesity and diabetes (discussed study by Zarzoso et al.)

Comparison

High-fat diet for 18 weeks vs Control diet

Design

Editorial

Follow-up

18 weeks

Authors

JMJohn MorrowElectrophysiology

Discussion

Member takes

Implication

A high-fat diet in a rabbit model induces electrophysiological abnormalities, including increased QTc and QT dispersion, providing insights into the mechanisms of sudden cardiac death in obesity and diabetes.

Structured PICO

Population

Rabbit model of obesity and diabetes (discussed study by Zarzoso et al.)

Intervention

High-fat diet (15% fat: 10% corn oil and 5% lard) for 18 weeks

Comparator

Control diet

Outcome

Electrophysiological abnormalities (QTc, QT dispersion, action potential duration)surrogate

Limitations

Lack of isolated cardiac myocyte patch clamp data to confirm the optical mapping of APD estimates
Lack of Western blot or gene expression data

Cite This Study

John Morrow (2014) studied this question.

synapsesocial.com/papers/6a7105ea26770c2b8de0e08c https://doi.org/10.1111/apha.12276

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High‐fat diet, obesity and sudden cardiac death

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

High‐fat diet, obesity and sudden cardiac death

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider