Mitochondrial energy metabolism is required for lifespan extension by the spastic paraplegia-associated protein spartin

Mitochondrial energy metabolism is required for lifespan extension by the spastic paraplegia-associated protein spartin – INTRODUCTION Troyer Syndrome, a complicated form of hereditary spastic paraplegias (HSPs), is caused by mutations in the gene coding for spartin (SPG20), resulting in a dysfunctional protein. This loss-of-function disease is characterized by neurological and musculoskeletal symptoms . Spartin is conserved throughout multicellular eukaryotes, although expressed in all tissues, it seems to be of particular importance (...)