Why the study?
Diabetic cardiomyopathy causes severe symptoms and is a major worldwide health problem, but the mechanisms by which exercise may prevent it warrant description.
Does regular exercise prevent diabetic cardiomyopathy and heart failure in patients with diabetes mellitus?
Does regular exercise prevent diabetic cardiomyopathy and heart failure in patients with diabetes mellitus?
Regular exercise may prevent diabetic cardiomyopathy and heart failure through multiple cardioprotective mechanisms including reduced apoptosis, fibrosis, and oxidative stress.
May support exercise in diabetes care to mitigate DCM; leaves open need for RCTs to confirm benefits.
Diabetes mellitus is associated with cardiovascular, ophthalmic, and renal comorbidities. Among these, diabetic cardiomyopathy (DCM) causes the most severe symptoms and is considered to be a major health problem worldwide. Exercise is widely known as an effective strategy for the prevention and treatment of many chronic diseases. Importantly, the onset of complications arising due to diabetes can be delayed or even prevented by exercise. Regular exercise is reported to have positive effects on diabetes mellitus and the development of DCM. The protective effects of exercise include prevention of cardiac apoptosis, fibrosis, oxidative stress, and microvascular diseases, as well as improvement in cardiac mitochondrial function and calcium regulation. This review summarizes the recent scientific findings to describe the potential mechanisms by which exercise may prevent DCM and heart failure.
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Seo et al. (2019) studied this question.
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