What question did this study set out to answer?

To investigate the immunologic response, precipitating antibody kinetics, and molecular characteristics of κ and λ carrageenans in rabbits.

September 1, 1968The Journal of ImmunologyOpen Access

The Immunologic Response of Rabbits to Carrageenans, Sulfated Galactans Extracted from Marine Algae

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Authors

KJKenneth H. JohnstonChilled Food Association EMEsther L. McCandlessMcMaster University

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Implication

Experimental animal study reveals distinct precipitating antibody responses to carrageenans in rabbits, indicating high immunologic specificity between algal galactan fractions.

Key Points

To investigate the immunologic response, precipitating antibody kinetics, and molecular characteristics of κ and λ carrageenans in rabbits.
Inoculated rabbits with κ and λ carrageenan sulfated galactans derived from marine algae to stimulate antibody production.
Assessed precipitation reaction kinetics and heterologous antigen-antibody cross-reactivity.
Calculated the molecular weight of the carrageenan antigens using the Boyd and Hooker equation.
Both κ and λ carrageenans stimulated the production of precipitating antibodies conforming to classic antipolysaccharide reaction kinetics.
Both carrageenan fractions demonstrated absolute immunologic specificity, showing no detectable cross-reaction between antigen and heterologous antibody.
Estimated the molecular weight of the λ carrageenan fraction at 350,000, while κ carrageenan values matched prior independent molecular weight determinations.

Cite This Study

Johnston et al. (1968) studied this question.

synapsesocial.com/papers/6a7107935d37378ac1de309f https://doi.org/10.4049/jimmunol.101.3.556

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Implication

Experimental animal study reveals distinct precipitating antibody responses to carrageenans in rabbits, indicating high immunologic specificity between algal galactan fractions.

The Immunologic Response of Rabbits to Carrageenans, Sulfated Galactans Extracted from Marine Algae

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Implication

Key Points

Cite This Study

The Immunologic Response of Rabbits to Carrageenans, Sulfated Galactans Extracted from Marine Algae

Discussion

Member takes

Implication

Key Points

Cite This Study

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