What question did this study set out to answer?

To evaluate the clinical significance of Campylobacter pyloridis isolation and investigate corresponding serum IgG and IgA antibody responses in patients undergoing upper gastrointestinal endoscopy.

February 1, 1986Journal of Clinical PathologyOpen Access

Clinical importance of Campylobacter pyloridis and associated serum IgG and IgA antibody responses in patients undergoing upper gastrointestinal endoscopy.

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Authors

LBLinda BoothPublic Health England GHG HoldstockHillingdon Hospital HMH MacBrideSouthampton General Hospital

Discussion

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Implication

Observational study reveals strong links between Campylobacter pyloridis antibodies, gastritis, and peptic ulcers in endoscopy patients, suggesting serology can serve as a noninvasive diagnostic tool.

Key Points

To evaluate the clinical significance of Campylobacter pyloridis isolation and investigate corresponding serum IgG and IgA antibody responses in patients undergoing upper gastrointestinal endoscopy.
Assessed 220 unselected adult patients undergoing diagnostic gastroscopy for the presence of C pyloridis, histological gastritis, and peptic ulceration.
Measured serum IgG and IgA antibody titres against a whole-cell sonicate of C pyloridis using an enzyme-linked immunosorbent assay (ELISA).
C pyloridis was isolated in 35% of patients (77/220) and was significantly associated with histological gastritis (p < 0.0001), duodenal ulcer (p < 0.0001), and gastric ulcer (p < 0.05).
Serum IgA and IgG antibody titres were significantly elevated in patients harboring C pyloridis compared to uninfected controls (p < 0.0001 for both).
Peptic ulceration or gastritis occurred in 100% of patients with high IgA titres and 78% with high IgG titres, compared to 18% and 9% in those with low titres, respectively.

Cite This Study

Booth et al. (1986) studied this question.

synapsesocial.com/papers/6a71082e2163a0a01bc53865 https://doi.org/10.1136/jcp.39.2.215

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February 1, 1986Journal of Clinical PathologyOpen Access

Clinical importance of Campylobacter pyloridis and associated serum IgG and IgA antibody responses in patients undergoing upper gastrointestinal endoscopy.

View Full Paper

Ask AI

Bookmark

Authors

LBLinda BoothPublic Health England GHG HoldstockHillingdon Hospital HMH MacBrideSouthampton General Hospital

Discussion

Member takes

Implication

Key Points

To evaluate the clinical significance of Campylobacter pyloridis isolation and investigate corresponding serum IgG and IgA antibody responses in patients undergoing upper gastrointestinal endoscopy.
Assessed 220 unselected adult patients undergoing diagnostic gastroscopy for the presence of C pyloridis, histological gastritis, and peptic ulceration.
Measured serum IgG and IgA antibody titres against a whole-cell sonicate of C pyloridis using an enzyme-linked immunosorbent assay (ELISA).
C pyloridis was isolated in 35% of patients (77/220) and was significantly associated with histological gastritis (p < 0.0001), duodenal ulcer (p < 0.0001), and gastric ulcer (p < 0.05).
Serum IgA and IgG antibody titres were significantly elevated in patients harboring C pyloridis compared to uninfected controls (p < 0.0001 for both).
Peptic ulceration or gastritis occurred in 100% of patients with high IgA titres and 78% with high IgG titres, compared to 18% and 9% in those with low titres, respectively.

Cite This Study

Booth et al. (1986) studied this question.

synapsesocial.com/papers/6a71082e2163a0a01bc53865 https://doi.org/10.1136/jcp.39.2.215

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

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