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March 1, 2003Journal of Biological ChemistryOpen Access

PYK2 Autophosphorylation, but Not Kinase Activity, Is Necessary for Adhesion-induced Association with c-Src, Osteoclast Spreading, and Bone Resorption

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Authors

PLPärvi T. LakkakorpiABAndrew J. BettMerck & Co., Inc., Rahway, NJ, USA (United States)LLLorraine LipfertRutgers, The State University of New Jersey

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Lakkakorpi et al. (2003) studied this question.

synapsesocial.com/papers/6a71083231a3df8243294294https://doi.org/10.1074/jbc.m206579200
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  2. 2Inhibition of osteoclastic bone resorption in vivo by echistatin, an "arginyl-glycyl-aspartyl" (RGD)-containing protein.1993 · 146 citations
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  5. 5PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinase.1998 · 251 citations