July 1, 1999Journal of Biological ChemistryOpen Access

Ion Channel Activity of the BH3 Only Bcl-2 Family Member, BID

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Population

Planar bilayers and liposomes (in vitro models)

Comparison

Amino-terminal truncated BIDDelta1-55 or… vs Full-length BID

Design

Preclinical

Authors

SSSharon L. SchendelLa Jolla Institute for Immunology RARustam AzimovUniversity of California, Los Angeles KPKrzysztof PawłowskiHoward Hughes Medical Institute

Discussion

Member takes

Implication

Cleavage may activate BID channels at physiological pH; leaves open its contribution to mitochondrial permeabilization in apoptosis.

Structured PICO

Population

Planar bilayers and liposomes (in vitro models)

Intervention

Amino-terminal truncated BIDDelta1-55 or Casp-8-cleaved BID

Comparator

Full-length BID

Outcome

Ion channel formation and activitysurrogate

BID exhibits ion channel-forming activity that is activated by proteolytic cleavage, suggesting structural and functional similarities with other Bcl-2 family proteins.

Cite This Study

Schendel et al. (1999) studied this question.

synapsesocial.com/papers/6a710866e5469ee92be1ab3a https://doi.org/10.1074/jbc.274.31.21932

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Ion Channel Activity of the BH3 Only Bcl-2 Family Member, BID

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Ion Channel Activity of the BH3 Only Bcl-2 Family Member, BID

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider