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April 26, 2019Current Vascular Pharmacology

Pharmacological Management of Cardiac Disease in Patients with Type 2 Diabetes: Insights into Clinical Practice

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Why the study?

Patients with type 2 diabetes mellitus require a multilevel therapeutic approach for primary and secondary prevention of cardiovascular disease, motivating a summary of recent high-level evidence.

Design

Literature review

Authors

DPDimitrios PatouliasKSKonstantinos StavropoulosΚIΚonstantinos Imprialos

Discussion

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Overview

Summarizes recent pharmacotherapy evidence for CVD in T2DM; leaves open optimal sequencing and combinations pending higher-level trials.

Structured PICO

P
Population
Patients with Type 2 Diabetes Mellitus (T2DM) requiring primary or secondary prevention of cardiovascular disease
I
Intervention
Pharmacological management including SGLT-2 inhibitors, GLP-1RAs, PCSK9 inhibitors, RAAS inhibitors, statins, aspirin, finerenone, and LCZ696

A comprehensive review highlighting the integration of novel drug classes with pleiotropic effects into the standard pharmacological management of cardiovascular disease in patients with type 2 diabetes.

Cite This Study

Patoulias et al. (2019) studied this question.

synapsesocial.com/papers/6a7108d4f44fa9f079decb9chttps://doi.org/10.2174/1570161117666190426162746
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diabetes and Hypertension: A Position Statement by the American Diabetes Association2017 · 735 citations
  2. 22013 ESH/ESC Guidelines for the management of arterial hypertension2013 · 13,687 citations
  3. 3Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes2015 · 4,524 citations
  4. 4Update on Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes Mellitus in Light of Recent Evidence: A Scientific Statement From the American Heart Association and the American Diabetes Association2015 · 495 citations
  5. 5Intensive Blood Glucose Control and Vascular Outcomes in Patients with Type 2 Diabetes2008 · 7,466 citations