Why the study?
The effect of TNAP on cardiac fibrosis remains controversial and its role in myocardial infarction-induced fibrosis and underlying mechanisms needed to be investigated.
Does TNAP inhibition attenuate cardiac fibrosis induced by myocardial infarction in preclinical models?
Does TNAP inhibition attenuate cardiac fibrosis induced by myocardial infarction in preclinical models?
TNAP inhibition with tetramisole attenuates post-MI cardiac fibrosis via AMPK-TGF-β1/Smads and p53 signaling pathways in preclinical models.
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May flag higher-risk MI patients; hypothesis-generating for TNAP targeting in fibrosis, requiring prospective validation.
Gao et al. (2020) studied this question.
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