What question did this study set out to answer?

To assess whether plasma cystatin C correlates with inulin clearance as effectively as plasma creatinine for measuring glomerular filtration rate in pediatric kidney disease.

June 1, 1998Clinical ChemistryOpen Access

Correlation of plasma concentrations of cystatin C and creatinine to inulin clearance in a pediatric population

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Authors

DSDouglas F. StickleThomas Jefferson University BCBarbara R. ColeBoston Children's Hospital KHKarl HockWashington University in St. Louis

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Implication

Comparative study reveals similar diagnostic utility between plasma cystatin C and creatinine relative to inulin clearance in children, suggesting cystatin C reliably estimates kidney function.

Key Points

To assess whether plasma cystatin C correlates with inulin clearance as effectively as plasma creatinine for measuring glomerular filtration rate in pediatric kidney disease.
Measured plasma cystatin C (cysC) and serum creatinine (SCR) in pediatric patients aged 4–19 years with kidney disease alongside gold-standard inulin clearance (C(IN)).
Stratified patients into two cohorts for evaluation: group A (ages 4–12 years, n = 26) and group B (ages 12–19 years, n = 34).
Compared inverse marker correlations against inulin clearance and established diagnostic performance using receiver-operator characteristic analyses.
Inverse linear correlation with inulin clearance was r = 0.765 in group A and r = 0.869 in group B for cysC, compared to r = 0.841 in group A and r = 0.892 in group B for SCR.
For detecting abnormal GFR (C(IN) ≤ 90 mL/min/1.73 m²), cysC >1.2 mg/L achieved 80% sensitivity and 91% specificity versus 67% sensitivity and 100% specificity for SCR >8.0 mg/L in group A.
In group B, cysC >1.4 mg/L achieved 87% sensitivity and 100% specificity versus 91% sensitivity and 91% specificity for SCR >9.0 mg/L; differences between markers were not statistically significant.

Cite This Study

Stickle et al. (1998) studied this question.

synapsesocial.com/papers/6a710bfeac440176ef29b847 https://doi.org/10.1093/clinchem/44.6.1334

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Implication

Comparative study reveals similar diagnostic utility between plasma cystatin C and creatinine relative to inulin clearance in children, suggesting cystatin C reliably estimates kidney function.

Correlation of plasma concentrations of cystatin C and creatinine to inulin clearance in a pediatric population

Discussion

Member takes

Implication

Key Points

Cite This Study

Correlation of plasma concentrations of cystatin C and creatinine to inulin clearance in a pediatric population

Discussion

Member takes

Implication

Key Points

Cite This Study

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