Three New Derivatives and Others Constituents from the Roots and Twigs of Trilepisium madagascariense DC

Three new compounds, trilepisflavene ( 1 ), trilepisdepsidone ( 2 ), and daturadiol stearate ( 3 ), together with nine known compounds, 2‐hydroxy‐4‐[(4‐hydroxy‐2‐methoxy‐6‐methylbenzoyl)oxy]‐6‐methylbenzoic acid ( 4 ), lichexanthone ( 5 ), naringenin ( 6 ), 3′,4′,5,7‐tetrahydroxyflavanone ( 7 ), 2‐hydroxybenzoic acid ( 8 ), methyl 2,4‐dihydroxy‐6‐methylbenzoate ( 9 ), β ‐amyrin ( 10 ), eurothridiol palmitate ( 11 ), and β ‐sitosterol ( 12 ), were isolated from the AcOEt extract of the twigs and the roots of Trilepisium madagascariense . Acetylation of eurothridiol palmitate was carried out and a new acetylated derivative ( 13 ) was obtained. The structures of the isolated and acetylated compounds were elucidated on the basis of spectroscopic analysis. Antimicrobial activity of all these compounds was evaluated using Mueller – Hinton broth (MHB) and Mueller – Hinton agar (MHA) method. Trilepisdepsidone , 2‐hydroxy‐4‐[(4‐hydroxy‐2‐methoxy‐6‐methylbenzoyl)oxy]‐6‐methylbenzoic acid, 3′,4′,5,7‐tetrahydroxyflavanone, and naringenin exhibited moderate to weak antimicrobial activity.