Why the study?
Does cumulative lifetime exposure to general anesthesia increase the risk of cognitive dysfunction in 75-year-old subjects?
Population
606 seventy-five-year-old subjects from a community-based age cohort in a geographical area of Vienna
Comparison
Cumulative lifetime exposure to general anesthesia vs No anesthesia (n=43) or fewer anesthesias
Design
Cohort
Authors
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Reassures against cumulative anesthesia as cognitive risk at 75; leaves open dominant roles of education, trauma, and environment in observational data.
Does cumulative lifetime exposure to general anesthesia increase the risk of cognitive dysfunction in 75-year-old subjects?
Cumulative exposure to general anesthesia over a lifetime does not appear to be associated with cognitive dysfunction at age 75.
Fischer et al. (2007) studied this question.
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