Key result
A recent case-control study concluding that general anesthesia does not increase Alzheimer disease risk was inadequately powered to detect the reported odds ratios of 1.28 to 1.63.
Why the study?
Does general anesthesia exposure increase the risk of developing Alzheimer disease?
Does general anesthesia exposure increase the risk of developing Alzheimer disease?
Effect estimate: OR 1.28-1.63
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This editorial highlights that prior studies showing no significant link between general anesthesia and Alzheimer disease may be severely underpowered, warning against false reassurance.
James F. Burris (1994) conducted a letter in Alzheimer disease (n=252). General anesthesia vs. No or lesser exposure to general anesthesia was evaluated on Alzheimer disease (OR 1.28-1.63). A recent case-control study concluding that general anesthesia does not increase Alzheimer disease risk was inadequately powered to detect the reported odds ratios of 1.28 to 1.63.
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