The assembly of nucleosomes and higher‐order chromatin structures has been extensively studied in vitro . Provided that non‐specific charge interactions are controlled, all the information for correct assembly is found to be inherent in the macromolecular components. Cellular extracts which can assemble chromatin in vitro with nucleosomes correctly spaced on the DNA have been studied in detail and also used to investigate the role of chromatin structure in transcription. However, the mechanisms of chromatin assembly in vivo are still controversial.
No takes yet. Share an insight, caveat, or question.
Dilworth et al. (1988) studied this question.
Synapse has enriched one closely related paper. Consider it for comparative context: