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November 1, 2003American Journal of Hypertension

Is it time to move to multidrug combinations?

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Why the study?

Do multidrug combinations at lower doses improve blood pressure control and reduce adverse effects compared to high-dose monotherapy in patients with hypertension?

Population

Patients with hypertension, particularly those with comorbid diabetes or renal disease

Comparison

Multidrug combinations vs Monotherapy

Design

Review

Authors

PJPool JlBaylor College of Medicine

Discussion

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Implication

Supports low-dose multidrug regimens for hypertension; leaves open need for outcome trials before practice change.

Structured PICO

Do multidrug combinations at lower doses improve blood pressure control and reduce adverse effects compared to high-dose monotherapy in patients with hypertension?

P
Population
Patients with hypertension, particularly those with comorbid diabetes or renal disease
I
Intervention
Multidrug combinations (two or more antihypertensive agents at lower doses)
C
Comparator
Monotherapy (higher doses of a single antihypertensive drug)

Multidrug combinations at lower doses are a more effective and better-tolerated strategy for achieving blood pressure targets in hypertensive patients compared to high-dose monotherapy.

Cite This Study

Pool Jl (2003) studied this question.

synapsesocial.com/papers/6a710dae439bab0cabc36ec6https://doi.org/10.1016/j.amjhyper.2003.07.005

Topics

Hypertension management
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