What question did this study set out to answer?

To evaluate the pathological consequences of nitric oxide deficiency and summarize clinical evidence for expanding the therapeutic use of nitric oxide donors beyond traditional cardiovascular targets.

July 16, 2008Expert Opinion on Pharmacotherapy

Nitric oxide: new evidence for novel therapeutic indications

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Authors

SWSunil J. WimalawansaBrunswick (United States)

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Implication

Review demonstrates the efficacy of nitric oxide donors across cardiovascular and skeletal disorders, highlighting broad therapeutic applications for aging populations.

Key Points

To evaluate the pathological consequences of nitric oxide deficiency and summarize clinical evidence for expanding the therapeutic use of nitric oxide donors beyond traditional cardiovascular targets.
Narrative review evaluating the physiological mechanisms of endogenous nitric oxide generation and degradation in human disease states.
Synthesis of clinical applications and therapeutic indications for exogenous nitric oxide donors, including nitrates and nitroglycerin.
Exogenous nitric oxide donors reliably compensate for defective nitric oxide synthase activity or excessive nitric oxide breakdown across multiple physiological systems, presenting minimal adverse effects predominantly limited to headaches.
Therapeutic utility extends beyond acute relief of angina and coronary artery disease to include osteoporosis, gastrointestinal motility disorders, pre-eclampsia, premature delivery, and postmenopausal vascular decline.

Cite This Study

Sunil J. Wimalawansa (2008) studied this question.

synapsesocial.com/papers/6a710dec78a11c550e0b184d https://doi.org/10.1517/14656566.9.11.1935

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Implication

Review demonstrates the efficacy of nitric oxide donors across cardiovascular and skeletal disorders, highlighting broad therapeutic applications for aging populations.

Nitric oxide: new evidence for novel therapeutic indications

Discussion

Member takes

Implication

Key Points

Cite This Study

Nitric oxide: new evidence for novel therapeutic indications

Discussion

Member takes

Implication

Key Points

Cite This Study

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