The T4 Lymphocyte in AIDS

The recent emergence of the acquired immunodeficiency syndrome (AIDS) has dramatically demonstrated the clinical importance of an intact immune system in the host's response to infectious disease and cancer. AIDS is represented by a spectrum of clinical abnormalities ranging from the most severe forms of opportunistic infections and unusual malignant processes to milder forms of AIDS-related syndromes in which the most consistent abnormalities are lymphadenopathy, fever, and weight loss. Associated with full-blown AIDS is the depression of virtually all measurable cellular and humoral immune responses despite paradoxical hypergammaglobulinemia. Immunodeficiency is also reflected in many in vitro findings, including diminution of . . .