Resolution of Refractory AIDS-Related Mucosal Candidiasis after Initiation of Didanosine plus Saquinavir

To the Editor: Mucosal candidiasis that is refractory to treatment with fluconazole is an increasingly common complication of human immunodeficiency virus (HIV) infection. In many cases, none of the available oral antifungal agents are effective; in some cases, even intravenous amphotericin B provides only partial relief. We describe a patient with fluconazole-resistant mucosal candidiasis whose infection resolved after the initiation of treatment with an antiretroviral agent combined with a protease inhibitor. A 34-year-old man with HIV infection had CD4 counts of 4 to 10 cells per cubic millimeter from November 1991 to January 1996. He received didanosine from January 1992 . . .