What question did this study set out to answer?

To review the functional consequences of NOD2 (CARD15) mutations on immune defense, tolerance, and susceptibility to inflammatory disorders such as Crohn's disease.

June 27, 2006Inflammatory Bowel DiseasesOpen Access

Functional consequences of NOD2 (CARD15) mutations

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Authors

CAClara AbrahamYale University JCJudy H. ChoRutgers, The State University of New Jersey

Discussion

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Implication

Review demonstrates impaired NF-kappaB activation and altered microbial defense driven by NOD2 mutations in inflammatory diseases, suggesting mechanisms underlying Crohn's disease susceptibility.

Key Points

To review the functional consequences of NOD2 (CARD15) mutations on immune defense, tolerance, and susceptibility to inflammatory disorders such as Crohn's disease.
Synthesized molecular, genetic, and immunological literature evaluating NOD2 activation by peptidoglycan, downstream NF-kappaB signaling, and interactions with Toll-like receptors.
Crohn's disease-associated NOD2 polymorphisms cause reduced NF-kappaB activation in response to bacterial peptidoglycan components.
Mutations disrupt intestinal defense against pathogens, impair immune tolerance to commensal bacteria, alter synergistic Toll-like receptor signaling, and increase risk for ileocolonic Crohn's disease, graft-versus-host disease mortality, and Blau syndrome.

Cite This Study

Abraham et al. (2006) studied this question.

synapsesocial.com/papers/6a710f8535aa2c282ce261f0 https://doi.org/10.1097/01.mib.0000225332.83861.5f

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Implication

Review demonstrates impaired NF-kappaB activation and altered microbial defense driven by NOD2 mutations in inflammatory diseases, suggesting mechanisms underlying Crohn's disease susceptibility.

Functional consequences of NOD2 (CARD15) mutations

Discussion

Member takes

Implication

Key Points

Cite This Study

Functional consequences of NOD2 (CARD15) mutations

Discussion

Member takes

Implication

Key Points

Cite This Study

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