Why the study?
The mechanisms by which G-protein-coupled receptor activation increases action potential activity in muscle afferents to produce the exercise pressor reflex are incompletely understood.
Does application of muscle contraction metabolites enhance NaV1.9 current in muscle afferent neurons?
Does application of muscle contraction metabolites enhance NaV1.9 current in muscle afferent neurons?
Enhancement of NaV1.9 current by muscle metabolites provides a potential mechanism for the exercise pressor reflex and its inappropriate activation in cardiovascular disease.
G-protein-coupled receptor (GPCR) activation increases action potential activity in muscle afferents to produce the exercise pressor reflex (EPR), but the mechanisms are incompletely understood. We provide evidence that Na V 1.9 current is synergistically enhanced by application of a mixture of metabolites potentially released during muscle contraction. The enhancement of Na V 1.9 current is likely one mechanism by which GPCR activation generates the EPR and the inappropriate activation of the EPR in patients with cardiovascular disease.
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Sukhanova et al. (2022) studied this question.
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