What question did this study set out to answer?

To determine the clinical and radiological characteristics of cardioembolic small subcortical infarcts in patients presenting with chronic atrial fibrillation.

March 1, 2001Journal of Neurology Neurosurgery & PsychiatryOpen Access

Atrial fibrillation with small subcortical infarcts

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Why the study?

What are the clinical and radiological characteristics of small subcortical infarcts in patients with atrial fibrillation compared to those without an embolic source?

Population

72 patients, comprising 27 with chronic atrial fibrillation and an isolated small subcortical infarct in the…

Design

Case-control

Authors

DJDoo-Gyo JungUniversity Hospital of Lausanne

Discussion

Member takes

Implication

No immediate clinical action warranted; hypothesis-generating observation in Level 4 data leaves mechanisms and relevance open for prospective study.

Key Points

To determine the clinical and radiological characteristics of cardioembolic small subcortical infarcts in patients presenting with chronic atrial fibrillation.
Compared 27 patients with chronic atrial fibrillation and isolated anterior circulation small subcortical infarcts (<1.5 cm diameter) against 45 age-matched controls without embolic sources.
Subgrouped atrial fibrillation patients into those with (n=22) and without (n=5) established small artery disease risk factors, specifically hypertension or diabetes mellitus.
Distribution of hypertension and diabetes did not differ significantly between groups, though neuropsychological disturbances occurred more frequently in the atrial fibrillation group than controls (15% vs 2%, p=0.066).
Patients lacking small artery disease risk factors had higher rates of secondary haemorrhagic transformation, faciobrachial pure motor weakness, subinsular involvement, and better recovery of neurological deficits.

Structured PICO

What are the clinical and radiological characteristics of small subcortical infarcts in patients with atrial fibrillation compared to those without an embolic source?

Population

72 patients, comprising 27 with chronic atrial fibrillation (AF) and an isolated small subcortical infarct (SSI) in the anterior circulation, and 45 age-matched controls with SSI but no arterial or cardiac embolic source.

Comparator

Age-matched patients with SSI but no arterial or cardiac embolic source (SSI-control group).

Outcome

Clinical and radiological characteristics of small subcortical infarcts.

Small subcortical infarcts in patients with atrial fibrillation can be caused by either small artery disease or cardioembolism, with specific clinical and radiological features helping to differentiate the two.

Cite This Study

Doo-Gyo Jung (2001) studied this question.

synapsesocial.com/papers/6a710fa231a3df8243294a2a https://doi.org/10.1136/jnnp.70.3.344

Topics

Atrial fibrillation Persistent AF management Anticoagulation in AF

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Implication

No immediate clinical action warranted; hypothesis-generating observation in Level 4 data leaves mechanisms and relevance open for prospective study.

Atrial fibrillation with small subcortical infarcts

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Atrial fibrillation with small subcortical infarcts

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider