What question did this study set out to answer?

To identify behavioral, demographic, and clinical determinants of HPV acquisition and clearance in young women with no prior evidence of HPV exposure.

August 29, 2019Sexually Transmitted DiseasesOpen Access

Determinants of Acquisition and Clearance of Human Papillomavirus Infection in Previously Unexposed Young Women

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Authors

MEMariam El‐ZeinMcGill University Health Centre ARAgnihotram V. RamanakumarMcGill University Health Centre PNPaulo NaudUniversity of Siena

Discussion

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Implication

Randomized trial reveals determinants of human papillomavirus acquisition and clearance in previously unexposed young women, indicating behavioral and demographic influences on viral persistence.

Key Points

To identify behavioral, demographic, and clinical determinants of HPV acquisition and clearance in young women with no prior evidence of HPV exposure.
Followed 534 women aged 15 to 25 years from Brazil, the United States, and Canada for 76 months across clinical trial cohorts (NCT00689741/NCT00120848).
Eligible participants were negative for cervical cytology, HPV DNA, and anti-HPV-16/18 antibodies at baseline.
Cervical samples were genotyped by polymerase chain reaction, and multivariable Cox proportional hazards models were used to estimate rate ratios (RR) across follow-up intervals.
During 0–27 months of follow-up, 257 women (48%) developed incident HPV infections (incidence rate = 30.11 per 1000 person-months; 95% CI, 26.64–34.02).
High-risk HPV acquisition was significantly associated with having 2 or more lifetime sexual partners (RR, 2.03; 95% CI, 1.37–3.02) and a history of any sexually transmitted disease (RR, 1.98; 95% CI, 1.19–3.29).
Over 76 months, high-risk HPV clearance was higher among North American women (RR, 1.38; 95% CI, 1.08–1.78) and Black women (RR, 1.64; 95% CI, 1.04–2.60), whereas having more lifetime partners decreased overall HPV clearance (RR, 0.65; 95% CI, 0.43–0.98).

Cite This Study

El‐Zein et al. (2019) studied this question.

synapsesocial.com/papers/6a710faa26a7f98052dd7e20 https://doi.org/10.1097/olq.0000000000001053

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Implication

Randomized trial reveals determinants of human papillomavirus acquisition and clearance in previously unexposed young women, indicating behavioral and demographic influences on viral persistence.

Determinants of Acquisition and Clearance of Human Papillomavirus Infection in Previously Unexposed Young Women

Discussion

Member takes

Implication

Key Points

Cite This Study

Determinants of Acquisition and Clearance of Human Papillomavirus Infection in Previously Unexposed Young Women

Discussion

Member takes

Implication

Key Points

Cite This Study

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