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The effect of Bacillus natto on T and B lymphocytes in the chicken spleen was investigated. Bacillus natto is isolated from fermented food and is used in Japan in a preparation that enhances growth of farm animals. When chickens were fed 10(7) colony-forming units of B. natto (in spores) per gram of feed from hatching to 27 days of age there was an increase in the percentage of T and B lymphocytes in the spleens compared with non-B. natto-fed controls. The findings suggested that dietary Bacillus natto had an effect on cellular immune responses.
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Inooka et al. (1986) studied this question.
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