Why the study?
Does genetic propensity for hypertension alter sensitivity to angiotensin and renin in rats?
Population
Two strains of rats with opposite genetic propensity for hypertension
Comparison
Injections of angiotensin and renin; high NaCl… vs Hypertension-resistant rats; low salt diet…
Design
Preclinical
Authors
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May indicate renin inhibitor role in genetic rat hypertension; leaves open human translation.
Does genetic propensity for hypertension alter sensitivity to angiotensin and renin in rats?
A renin inhibitor present in hypertension-prone rats may increase sensitivity to angiotensin and contribute to the development of hypertension.
Iwai et al. (1970) studied this question.
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