Polycystic ovary syndrome as a developmental disorder

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women, characterized by anovulation, hyperandrogenism and polycystic ovaries at ultrasonography. In addition to its reproductive consequences, PCOS is associated with metabolic abnormalities of which altered sensitivity to insulin appears to play a pivotal role in the development of the disorder. Currently, PCOS is considered to be a developmental disorder with varying clinical presentations depending on age. This review provides an overview of the manifestations associated with PCOS from preconception until the post-reproductive years.