Population
Isolated rodent ventricular cardiac myocytes predominantly expressing alpha-MyHC
Comparison
Acute genetic engineering with a recombinant… vs Control myocytes
Design
Preclinical
Authors
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May impair human contractility at low expression; leaves open clinical relevance pending human studies.
Small increases in beta-MyHC expression directly decrease intact cardiac myocyte contractility independent of calcium transients, demonstrating its role as a negative inotrope.
Herron et al. (2007) studied this question.
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