Why the study?
Does Tissue Doppler Imaging detect early diastolic dysfunction in Maine Coon cats with a myosin binding protein C mutation before hypertrophy development?
Population
27 cats: 6 normal domestic shorthair cats, 6 Maine Coon cats with abnormal cardiac myosin binding protein C…
Comparison
Tissue Doppler imaging of the lateral mitral… vs Comparison between normal cats, genotypically…
Design
Preclinical
Authors
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TDI parameters track severity in this model; leaves open utility for screening phenotypically normal mutation carriers.
Does Tissue Doppler Imaging detect early diastolic dysfunction in Maine Coon cats with a myosin binding protein C mutation before hypertrophy development?
Diastolic dysfunction occurs before hypertrophy in Maine Coon cats with a myosin binding protein C mutation, but TDI is an insensitive screening test for phenotypically normal, genotypically affected cats.
MacDonald et al. (2007) studied this question.
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