Population
Transgenic (TG) mice and wild-type (non-TG) mice
Comparison
Expression of human cTnT1 isoform vs Wild-type (non-TG) mice
Design
Preclinical
Authors
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May impair contractility in development and disease; leaves open relevance to human heart failure.
The human cardiac troponin T isoform hcTnT1, expressed during development and heart disease, decreases myofilament tension and alters left ventricular pressure waveforms in a transgenic mouse model.
Nassar et al. (2004) studied this question.
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