What question did this study set out to answer?

To review the mechanisms by which disseminated intravascular coagulation-induced microvascular thrombosis leads to multiple organ dysfunction syndrome, focusing on its interplay with systemic inflammatory response syndrome.

February 1, 2010Critical Care Medicine

Microvascular thrombosis and multiple organ dysfunction syndrome

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Authors

SGSatoshi GandoSapporo University

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Implication

Narrative review reveals microvascular thrombosis drives multiple organ dysfunction in critically ill patients, highlighting synergistic interactions between systemic inflammation and coagulation.

Key Points

To review the mechanisms by which disseminated intravascular coagulation-induced microvascular thrombosis leads to multiple organ dysfunction syndrome, focusing on its interplay with systemic inflammatory response syndrome.
Synthesized findings from published clinical, experimental, and autopsy literature evaluating microvascular thrombosis and organ damage in critical illness.
Histologic evaluations consistently demonstrate microvascular thrombosis, organ tissue injury, and excessive fibrin deposition in disseminated intravascular coagulation.
Neutrophil-endothelial activation driven by proinflammatory cytokines and signaling via protease-activated receptors mediate mutual amplification between coagulation and inflammatory cascades.
Systemic inflammatory response syndrome and disseminated intravascular coagulation act synergistically to precipitate multiple organ dysfunction syndrome and drive adverse clinical outcomes.

Cite This Study

Satoshi Gando (2010) studied this question.

synapsesocial.com/papers/6a71107ece524a4339c4b16f https://doi.org/10.1097/ccm.0b013e3181c9e31d

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Implication

Narrative review reveals microvascular thrombosis drives multiple organ dysfunction in critically ill patients, highlighting synergistic interactions between systemic inflammation and coagulation.

Microvascular thrombosis and multiple organ dysfunction syndrome

Discussion

Member takes

Implication

Key Points

Cite This Study

Microvascular thrombosis and multiple organ dysfunction syndrome

Discussion

Member takes

Implication

Key Points

Cite This Study

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