Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 1, 1981Proceedings of the National Academy of SciencesOpen Access

Substrate proteins for calmodulin-sensitive and phospholipid-sensitive Ca2+-dependent protein kinases in heart, and inhibition of their phosphorylation by palmitoylcarnitine.

View Full Paper
Ask AI
Bookmark
Share

Population

Guinea pig heart

Design

Preclinical

Authors

NKNorio KatohHokkaido University of ScienceRWRobert W. WrennAugusta UniversityBWBradley C. WiseTampa General Hospital

Discussion

Loading...

Member takes

Implication

May link palmitoylcarnitine to ischemic kinase inhibition in animal tissue; leaves open human relevance and therapeutic implications.

Structured PICO

P
Population
Guinea pig heart (cytosol and particulate subfractions enriched in nuclei, mitochondria, microsome, or plasma membrane)
I
Intervention
Palmitoylcarnitine
O
Outcome
Phosphorylation of endogenous substrates for phospholipid-sensitive and calmodulin-sensitive Ca2+-dependent protein kinasessurrogate

The inhibition of Ca2+-dependent phosphorylation of cardiac proteins by palmitoylcarnitine may be related to the accumulation of this fatty acid intermediate during myocardial ischemia.

Cite This Study

Katoh et al. (1981) studied this question.

synapsesocial.com/papers/6a711378f44fa9f079ded90bhttps://doi.org/10.1073/pnas.78.8.4813
View Full Paper
Ask AI
Bookmark
Share