Why the study?
Does long-term use of NSAIDs increase the risk of cardiovascular thrombotic events?
Population
Patients from 14 clinical trials and 16 observational studies evaluating long-term use of NSAIDs
Design
Review
Follow-up
at least 6 months
Authors
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May warrant individualized CV risk assessment with long-term high-dose rofecoxib or diclofenac; leaves open comparative thrombotic risks of other NSAIDs.
Does long-term use of NSAIDs increase the risk of cardiovascular thrombotic events?
Long-term use of high-dose rofecoxib and possibly diclofenac is associated with an increased risk of cardiovascular events, though the relative risk for most NSAIDs remains below 2.
Salvo et al. (2014) studied this question.
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