Key result
Tumour dopa secretion occurs in ~18% of phaeochromocytomas and is linked to normotension despite elevated catecholamines.
Observational (n=11)
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In a series of 11 cases with phaeochromocytoma, two patients were found in whom the tumour secreted dopa in addition to dopamine, noradrenaline, and adrenaline. These two patients were normotensive in spite of high plasma and urinary levels of noradrenaline and adrenaline. This raises the possibility that dopa may be able to protect against the hypertensive action of noradrenaline. Such a mechanism would also explain the absence of hypertension in many cases of neuroblastoma.
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Louis et al. (1972) conducted an observational in Phaeochromocytoma (n=11). Tumour secretion of dopa vs. Absence of dopa secretion was evaluated on Dopa secretion and blood pressure status. Tumour secretion of dopa occurred in 2 of 11 (18.2%) phaeochromocytoma cases, and both patients remained normotensive despite elevated noradrenaline and adrenaline levels.
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