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September 5, 2009European Journal of Anaesthesiology

Prognostic role of insulin resistance as assessed by homeostatic model assessment index in the acute phase of myocardial infarction in nondiabetic patients submitted to percutaneous coronary intervention

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Why the study?

Does insulin resistance assessed by HOMA index predict early and late mortality in nondiabetic STEMI patients undergoing PCI?

Population

253 consecutive nondiabetic patients with ST elevation myocardial infarction submitted to percutaneous…

Comparison

Insulin resistance assessed by homeostatic model… vs Patients without insulin resistance / lower HOMA…

Design

Cohort

Follow-up

long-term

Authors

CLChiara LazzeriASAndrea SoriMCMarco Chiostri

Discussion

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Member takes

Overview

HOMA index may refine early mortality risk stratification in nondiabetic STEMI; hypothesis-generating for insulin resistance interventions.

Structured PICO

Does insulin resistance assessed by HOMA index predict early and late mortality in nondiabetic STEMI patients undergoing PCI?

P
Population
253 consecutive nondiabetic patients with ST elevation myocardial infarction (STEMI) submitted to percutaneous coronary intervention
I
Intervention
Insulin resistance assessed by homeostatic model assessment (HOMA) index
C
Comparator
Patients without insulin resistance / lower HOMA index
O
Outcome
Early (intra-intensive cardiac care unit) and late mortalityhard clinical

Insulin resistance is common in nondiabetic STEMI patients undergoing PCI and serves as an independent predictor of in-hospital mortality.

Cite This Study

Lazzeri et al. (2009) studied this question.

synapsesocial.com/papers/6a71188cfe4101aa97e06eb2https://doi.org/10.1097/eja.0b013e32832a235c
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Effect of Insulin Resistance on Prognosis of Non-Diabetic Patients Who Underwent Percutaneous Coronary Intervention2006 · 18 citations
  2. 2Optimal Medical Therapy with or without PCI for Stable Coronary Disease2007 · 4,721 citations
  3. 3Acute hyperglycaemia: a ‘new’ risk factor during myocardial infarction2004 · 147 citations
  4. 4Repeatability Characteristics of Simple Indices of Insulin Resistance: Implications for Research Applications2001 · 358 citations
  5. 5Hyperglycemia and Acute Coronary Syndrome2008 · 497 citations