Why the study?
Do polymorphisms in the alpha2 subunit gene affect platelet alpha2beta1 receptor density and susceptibility to CAD in cardiac surgery patients?
Population
254 cardiac surgery patients
Design
Cross-sectional
Authors
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No CAD association in this cohort; leaves open combined variant effects on alpha2beta1 density as a potential thrombotic mechanism.
Do polymorphisms in the alpha2 subunit gene affect platelet alpha2beta1 receptor density and susceptibility to CAD in cardiac surgery patients?
Polymorphisms in the coding and promoter sequences of the alpha2 gene act in combination to modulate platelet alpha2beta1 receptor density, though they are not directly associated with CAD susceptibility.
Ajzenberg et al. (2005) studied this question.
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