Modification of Magnetite Cellulose Nanoparticles via Click Reaction for use in Controlled Drug Delivery

Superparamagnetic Fe3O4 nanoparticles (MNPs) were functionalized by modified cellulose. The modified cellulose was synthesized through bromoacetylation of cellulose (BACell) followed by the substitution of sodium azide to form BACell-N3. The remaining methylene bromide groups on BACell-N3 was further reacted with the MNPs to form Fe3O4/Cell-N3. Then propargyl alcohol (PA) was immobilized on the azide-terminated Fe3O4 nanoparticles through copper (I)-catalyzed azide-alkyne cycloaddition (click reaction) to form Fe3O4/Cell/TAA nanoparticles. Doxorubicin (DOX) was loaded on prepared nanoparticles and release profiles of the DOX as a model drug from the Fe3O4/Cell/TAA nanoparticles and its loading capacity were determined by UV–Vis absorption at λmax 483 nm.