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Early repolarization may confer higher sudden death risk than assumed; hypothesis-generating and requires prospective validation before practice change.
Early repolarization pattern has been long considered as a benign electocardiographic manifestation. Recent publications however, have drawn attention to increased incidence of sudden cardiac death in this population, suggesting that it is no more a benign condition. As the scientific community is geared towards studying its natural history, pathogenetic mechanism, risk pattern, debate has been raised regarding the nomenclature, pathogenesis and mechanistic issues. Heterogeneity in the population studied and diversity in definitions used make calculating exact odds of risk complicated. However recent publication of definite and probable criteria for diagnosis of ER may bring some semblance to the ongoing debate.
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Mishra et al. (2014) studied this question.
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