Arterial hypertension and breast cancer in women: mechanisms of comorbidity and iatrogenic disease

The combination of hypertension (HTN) and breast cancer (BC) is one of the most frequent clinical variants of comorbidity of cardiovascular and oncological diseases. Each of these pathologies is associated with risk factors, which are cross-cutting. The review presents an analysis of pathophysiological processes characterizing the nonrandomness of the co-existence of HTN and BC (chronic systemic inflammation, oxidative stress, endothelial and mitochondrial dysfunction, accelerated cellular aging, and other). Antitumor therapy of BC is often associated with vasculotoxic effects that provoke a transient or sustained increase in blood pressure. Adverse cardiovascular events may interfere with the implementation of antitumor therapy of BC. Interdisciplinary cooperation of cardiologists and oncologists in HTN and BC comorbidity will allow personifying algorithms for the prevention, diagnosis and treatment of these pathologies.