Why the study?
Does overweightness or obesity increase arterial stiffness in healthy subjects without overt cardiovascular disease?
Does overweightness or obesity increase arterial stiffness in healthy subjects without overt cardiovascular disease?
Overweightness and obesity are associated with increased arterial stiffness in healthy individuals without overt cardiovascular disease, indicating early vascular risk.
Obesity elevates arterial stiffness in healthy adults; confirms association and extends evidence for early vascular risk stratification.
OBJECTIVE: The relationship between overweightness, obesity and arterial stiffness remains unclear. We performed a meta-analysis evaluating the impact of obesity/overweightness on arterial stiffness in healthy subjects. METHODS: Literature searches were conducted using databases (eg, MEDLINE, EMBASE) and citations cross-referenced. Studies evaluating the relationship between obesity/overweightness and cfPWV, baPWV, and AIx were systematically searched. A total of 10 studies (1,124 obese/overweight subjects, 1,884 controls) were included. RESULTS: Compared to controls, obese/overweight subjects showed a significantly higher cfPWV (SMD 0.50 m/s; 95%CI 0.15, 0.86; P = 0.005), baPWV (SMD 0.41 m/s; 95% CI 0.08, 0.74; P = 0.014), and AIx (SMD 1.02；95%CI 0.16, 1.87; P < 0.0001). When analyzing 'high quality' studies, the difference in arterial stiffness among obese/overweight subjects and controls remain (SMD 0.73 m/s; 95%CI 0.16, 1.30; P = 0.013). CONCLUSION: Arterial stiffness, a recognized marker of cardio vascular risk, is increased in obese/overweight subjects without overt cardiovascular diseases.
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Li et al. (2016) studied this question.
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