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Taking direction well: Substituted phenylalanine derivatives were prepared by CH bond functionalization (see scheme). The syntheses are highly convergent and employ an N-phthaloylalanine with a 2-thiomethylaniline directing group. The use of an 8-aminoquinoline directing group allows for the diarylation of methyl and the diastereoselective arylation of methylene groups.
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Tran et al. (2012) studied this question.
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