Key result
Heterozygous familial hypercholesterolemia prevalence reaches ~7-fold higher levels in young Johannesburg Jewish men.
Cross-Sectional (n=403)
Answers are grounded in this paper and cite their sources.
The prevalence of heterozygous familial hypercholesterolemia was determined in a representative sample of 403 young Jewish men resident in Johannesburg, South Africa. Preliminary screening by measurement of serum total cholesterol demonstrated that 25 of them had levels greater than or equal to 7.5 mmol/l (290 mg/dl). On the basis of subsequent clinical, biochemical, and family studies, 6 men, or about 1 in 67 of the total sample, were considered to be heterozygotes. This very high prevalence, about 7 times greater than that found in other Caucasian populations, is probably related to founder effect. It may help to explain the high frequency of coronary heart disease in Johannesburg Jews.
No takes yet. Share an insight, caveat, or question.
Seftel et al. (1989) conducted a cross-sectional in Heterozygous familial hypercholesterolemia (n=403). Jewish ancestry in Johannesburg vs. Other Caucasian populations was evaluated on Prevalence of heterozygous familial hypercholesterolemia. Young Jewish men in Johannesburg had a 1.49% (1 in 67) prevalence of heterozygous familial hypercholesterolemia, about 7 times greater than in other Caucasian populations.
Synapse has enriched 10 related papers. Consider them for comparative context: