Why the study?
Does early atherosclerosis induced by a high cholesterol diet impair endothelium-dependent dilation in Macaca fascicularis monkeys?
Population
14 Macaca fascicularis monkeys (two groups of seven)
Comparison
High cholesterol diet for 11 months vs Control diet
Design
Preclinical
Follow-up
11 months
Authors
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Early endothelial impairment precedes stenotic lesions in this primate model; extends prior observations but leaves open human translation.
Does early atherosclerosis induced by a high cholesterol diet impair endothelium-dependent dilation in Macaca fascicularis monkeys?
Endothelium-dependent vasodilation is lost early in the development of atherosclerosis, before the appearance of stenosing and occlusive disease.
McLenachan et al. (1991) studied this question.
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