Effects of dietary supplementation of creatine on fetal development in gilts at d 60 and d 90 of gestation

Arianna N. Lopez; M. Olivarez; Claire Stenhouse; Robyn M Moses; Makenzie G Newton; Nirvay Sah; Heewon Seo; Joseph C. Cain; Carli Lefevre; A. Catharine Ross; Patrick Ryan; Jeffrey Wiegert; Guoyao Wu; Gregory A. Johnson; Fuller W. Bazer

doi:10.1186/s40104-025-01166-0

March 1, 2025Journal of Animal Science and Biotechnology/Journal of animal science and biotechnologyOpen Access

Effects of dietary supplementation of creatine on fetal development in gilts at d 60 and d 90 of gestation

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Key Points

To determine the effects of maternal dietary creatine supplementation on fetal development, organ weights, and muscle characteristics in gilts at days 60 and 90 of gestation.
Assigned gestating gilts across two seasonal replicates (n = 20 gilts/replicate) to either a standard control diet or 30 g/day creatine monohydrate from day 10 to day 60 or day 90 of gestation.
Conducted hysterectomies at day 60 or day 90 to measure litter size, crown-rump length, fetal weight, and the weights of fetal brain, kidney, liver, spleen, and biceps femoris muscle.
Dietary supplementation with creatine significantly enhanced the development and weight of select fetal organs in gestating gilts.
Creatine treatment positively influenced fetal growth parameters across mid-to-late gestation, confirming functional roles of the creatine-creatine kinase-phosphocreatine system.

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Implication

Controlled trial demonstrates dietary creatine supplementation enhances select fetal organ development in gestating gilts, indicating a critical role of cellular energy pathways in pregnancy.

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Lopez et al. (2025) studied this question.

synapsesocial.com/papers/6a711dc38031ec7bb1dcc549 https://doi.org/10.1186/s40104-025-01166-0

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Effects of dietary supplementation of creatine on fetal development in gilts at d 60 and d 90 of gestation

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Effects of dietary supplementation of creatine on fetal development in gilts at d 60 and d 90 of gestation

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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