Why the study?
Does intraperitoneal injection of monoclonal anti-rat T-lymphocyte antibodies alter T-cell populations and affect the onset of experimental allergic neuritis in rats?
Does intraperitoneal injection of monoclonal anti-rat T-lymphocyte antibodies alter T-cell populations and affect the onset of experimental allergic neuritis in rats?
Monoclonal anti-T-cell antibodies have differential effects on T-cell subpopulations and can either prevent or exacerbate experimental allergic neuritis in rats depending on the targeted T-cell subset.
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Preclinical T-cell subset targeting modulates neuritis in rats; leaves open human translation and requires prospective study.
Holmdahl et al. (1985) studied this question.
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