Apoptosis-inducing factor (AIF) mediates PARP-1-dependent glutamate excitotoxicity in a caspase-independent manner, substituting for caspase executioners in NMDA-triggered neuronal death.
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AIF may mediate caspase-independent excitotoxicity; leaves open its viability as a therapeutic target pending human validation.
Wang et al. (2004) studied this question.
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