What question did this study set out to answer?

This research aims to identify biomarkers for left-ventricular diastolic dysfunction (LVDD) in non-diabetic chronic kidney disease (CKD) patients.

October 25, 2011Nephron ExtraOpen Access

Serum High-Sensitivity Cardiac Troponin T Is a Significant Biomarker of Left-Ventricular Diastolic Dysfunction in Subjects with Non-Diabetic Chronic Kidney Disease

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Why the study?

Is high-sensitivity cardiac troponin T a significant biomarker for detecting left-ventricular diastolic dysfunction in patients with non-diabetic chronic kidney disease?

Population

93 patients with non-diabetic chronic kidney disease (CKD)

Design

Cross-sectional

Authors

MKMasashi KitagawaOkayama University HSHitoshi SugiyamaOkayama University HMHiroshi MorinagaOkayama University

Discussion

Member takes

Implication

hs-cTnT may detect LVDD in non-diabetic CKD; hypothesis-generating and requires prospective validation before clinical use.

Key Points

This research aims to identify biomarkers for left-ventricular diastolic dysfunction (LVDD) in non-diabetic chronic kidney disease (CKD) patients.
Evaluated relationships among echocardiography, hs-cTnT, BNP, and renal function in 93 CKD patients.
Recorded LV mass index, E, E', and E/E' ratios to assess diastolic function.
Performed multivariate analysis to investigate associations with E'.
Patients with LVDD (E' <5 cm/s) had significantly higher hs-cTnT levels (p = 0.0101) compared to those with E' ≥5 cm/s.
The area under the ROC curve for hs-cTnT detection of E' <5 cm/s was 0.880, indicating good predictive capacity.
Hs-cTnT and albuminuria were significantly associated with E', indicating its relevance in assessing diastolic dysfunction.

Structured PICO

Is high-sensitivity cardiac troponin T a significant biomarker for detecting left-ventricular diastolic dysfunction in patients with non-diabetic chronic kidney disease?

Population

93 patients with non-diabetic chronic kidney disease (CKD)

Intervention

Measurement of high-sensitivity cardiac troponin T (hs-cTnT) and B-type natriuretic peptide (BNP)

Outcome

Left-ventricular diastolic dysfunction (LVDD) defined by peak early diastolic mitral annular velocity (E') <5 cm/ssurrogate

High-sensitivity cardiac troponin T is a strong biomarker for detecting left-ventricular diastolic dysfunction in patients with non-diabetic chronic kidney disease.

Cite This Study

Kitagawa et al. (2011) studied this question.

synapsesocial.com/papers/6a711de284cc45bb7bdfe23c https://doi.org/10.1159/000333801

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Serum High-Sensitivity Cardiac Troponin T Is a Significant Biomarker of Left-Ventricular Diastolic Dysfunction in Subjects with Non-Diabetic Chronic Kidney Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Serum High-Sensitivity Cardiac Troponin T Is a Significant Biomarker of Left-Ventricular Diastolic Dysfunction in Subjects with Non-Diabetic Chronic Kidney Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider